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广州快乐十分加奖:Universal and robust assessment of circadian time?
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In PNAS, Braun et al. (1) describe the algorithm TimeSignature. We make the following observations.
First, circadian time refers to the phase of internal biological clocks. Any algorithm assessing this should be validated against gold-standard markers of internal circadian phase. For example, the phase of the melatonin rhythm is considered a gold standard for the phase of the suprachiasmatic nucleus, the master circadian pacemaker in mammals. Braun et al. (1) validate TimeSignature against the clock time at which the sample was taken, which is not a marker of internal phase. It is unfortunate the authors do not discuss this major limitation and claim to assess circadian time. Others (e.g., refs. 2 and …
?1To whom correspondence should be addressed. Email: .