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快乐十分任四复式玩法:Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1
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Deciphering the rules that shape neuronal connections is critical to our understanding of information processing in a neural network. Our study describes how the relative timing of the activities of afferents and their associated postsynaptic neurons determines synaptic strength at the hippocampal CA1 circuit, an area important for learning and memory. A low number of repeated, paired activities between afferents and their neurons differentially shapes the hippocampal CA3–CA1 synaptic pathway for hours and even affects how future information is processed in the neuronal ensemble.
In spike-timing-dependent plasticity (STDP), the direction and degree of synaptic modification are determined by the coherence of pre- and postsynaptic activities within a neuron. However, in the adult rat hippocampus, it remains unclear whether STDP-like mechanisms in a neuronal population induce synaptic potentiation of a long duration. Thus, we asked whether the magnitude and maintenance of synaptic plasticity in a population of CA1 neurons differ as a function of the temporal order and interval between pre- and postsynaptic activities. Modulation of the relative timing of Schaffer collateral fibers (presynaptic component) and CA1 axons (postsynaptic component) stimulations resulted in an asymmetric population STDP (pSTDP). The resulting potentiation in response to 20 pairings at 1 Hz was largest in magnitude and most persistent (4 h) when presynaptic activity coincided with or preceded postsynaptic activity. Interestingly, when postsynaptic activation preceded presynaptic stimulation by 20 ms, an immediate increase in field excitatory postsynaptic potentials was observed, but it eventually transformed into a synaptic depression. Furthermore, pSTDP engaged in selective forms of late-associative activity: It facilitated the maintenance of tetanization-induced early long-term potentiation (LTP) in neighboring synapses but not early long-term depression, reflecting possible mechanistic differences with classical tetanization-induced LTP. The data demonstrate that a pairing of pre- and postsynaptic activities in a neuronal population can greatly reduce the required number of synaptic plasticity-evoking events and induce a potentiation of a degree and duration similar to that with repeated tetanization. Thus, pSTDP determines synaptic efficacy in the hippocampal CA3–CA1 circuit and could bias the CA1 neuronal population toward potentiation in future events.
?1M.S. and K.K.-K. contributed equally to this work.
- ?2To whom correspondence may be addressed. Email: or .
Author contributions: K.K.L.P., M.S., K.K.-K., T.B., and S.S. designed research; K.K.L.P., M.S., K.K.-K., T.B., and S.S. performed research; K.K.L.P., M.S., K.K.-K., T.B., and S.S. analyzed data; and K.K.L.P., M.S., T.B., and S.S. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1817643116/-/DCSupplemental.
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